TNF receptor-associated periodic syndrome (TRAPS)

TRAPS has a worldwide distribution, but it is a very rare condition. In Belgium only a few dozen patients have been identified. At present there are several hundred patients known worldwide.

 

Signs and symptoms

The age of the first attack varies greatly from patient to patient, but most patients get the first symptoms in childhood. TRAPS attacks generally last longer than the fever attacks in the other auto-inflammatory syndromes. Inflammatory attacks can take weeks to resolve. The attacks are accompanied by fever, muscle pains in the limbs and gastrointestinal symptoms such as abdominal pain, often accompanied by vomiting and constipation. In addition, many patients have arthritis and skin rashes.

 

Genetics

TRAPS is a so-called autosomal dominant condition. This means that a mutation in only one of the two genes leads to the disease. Most patients therefore have a family history with several relatives with the same condition. To date, there are more than 50 different mutations described TNFRSF1A